2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128833
    Bis-NH2-PEG2 929-59-9 99.82%
    Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-NH2-PEG2
  • HY-140915
    Biotin-PEG4-Picolyl azide 2222687-71-8 98.66%
    Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Picolyl azide
  • HY-W008296
    NH2-C6-NH-Boc 51857-17-1 99.77%
    NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.
    NH2-C6-NH-Boc
  • HY-30755
    7-Boc-(2,7-Diazaspiro[3.5]nonane) 896464-16-7 99.82%
    7-Boc-(2,7-Diazaspiro[3.5]nonane) is a PROTAC linker that can be used in the synthesis of PROTACs.
    7-Boc-(2,7-Diazaspiro[3.5]nonane)
  • HY-133399
    Alkyne-PEG4-maleimide 1609651-90-2 98.44%
    Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alkyne-PEG4-maleimide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-PEG4-maleimide
  • HY-42569
    Methyl 3-hydroxypropanoate 6149-41-3 99.83%
    Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl 3-hydroxypropanoate
  • HY-130211
    Azido-PEG5-alcohol 86770-68-5
    Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-alcohol
  • HY-W008279
    Amino-PEG2-NH-Boc 127828-22-2 98.0%
    Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG2-NH-Boc
  • HY-Y1139
    Pimelic acid 111-16-0 ≥98.0%
    Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism.
    Pimelic acid
  • HY-W006524
    H2N-PEG2-CH2COOH 134978-97-5 99.87%
    H2N-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    H2N-PEG2-CH2COOH
  • HY-135804
    NH2-PEG3-C2-Boc 252881-74-6
    NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-Boc
  • HY-W015943
    Hex-5-yn-1-ol 928-90-5 99.82%
    Hex-5-yn-1-ol (5-Hexyn-1-ol) is a PROTAC linker that can be used in the synthesis of PROTACs.
    Hex-5-yn-1-ol
  • HY-W072752
    endo-BCN-PEG2-NH2 1263166-93-3
    endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG2-NH2 contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG2-NH2
  • HY-140215
    Azido-PEG6-amine 957486-82-7
    Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-amine
  • HY-W040238
    Fmoc-NH-PEG2-CH2CH2COOH 872679-70-4 99.79%
    Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG2-CH2CH2COOH
  • HY-40178
    NH2-C4-NH-Boc 68076-36-8 99.98%
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    NH2-C4-NH-Boc
  • HY-140696
    m-PEG2000-OH 9004-74-4
    m-PEG2000-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG2000-OH
  • HY-133388
    Boc-NH-C12-NH2 109792-60-1 99.99%
    Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C12-NH2
  • HY-33366
    Boc-NH-PEG3-CH2COOH 462100-06-7
    Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG3-CH2COOH
  • HY-W040231
    Fmoc-NH-PEG3-CH2CH2COOH 867062-95-1 99.65%
    Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG3-CH2CH2COOH
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.